Angiotensin II, aldosterone and arterial pressure: a quantitative approach. Arthur C. Corcoran Memorial Lecture.

Arthur C. Corcoran Memorial Lecture. Sympathetic activity, vascular capacitance, and long-term regulation of arterial pressure.

I am honored to have been chosen to present the 2008 Arthur C. Corcoran Memorial Lecture, because Dr Corcoran was both a brilliant scientist and one of the founding fathers in the field of hypertension research, but I am particularly gratified to join the list of superb scientists who have preceded me as Corcoran lecturers. When I began studying hypertension as a postdoctoral fellow, under the ...

Bartter's syndrome: a disorder of vascular reactivity. Arthur C. Corcoran Memorial Lecture.

Deciphering the roles of tissue renin-angiotensin systems in whole animals.

I am both grateful and humbled to have been invited to give the 2010 Arthur C. Corcoran memorial lecture. I want to thank not only those who nominated and selected me for this prestigious recognition but also all of the trainees, colleagues, and collaborators who have helped to refine the ideas that motivate the research and provide the engine for its realization. Although my group has worked o...

Corcoran lecture: the case for or against salt in hypertension. Arthur Curtis Corcoran, MD (1909-1965). Tribute and prelude to Corcoran Lecture of 1988.

Salt intake in excess of body needs has long been considered a factor in the genesis and maintenance of human hypertension; the mechanism is salt retention due to faulty renal excretory efficiency. This discussion reviews clinical studies that make a case either for or against the salt hypothesis. Included is a summary of recent experiences with 4 days of salt depletion and 3 days of salt loadi...

The renin-angiotensin system and aldosterone secretion during sodium depletion in the rat.

The role of the renin-angiotensin system in the control of aldosterone secretion was studied in the sodium-depleted rat. Administration of angiotensin II produced a significant increase in aldosterone secretion and arterial blood pressure in normal rats; simultaneous infusion of the angiotensin analogue, l-sarcosine-8-alanine-angiotensin II, blocked both the pressor and the steroidogenic action...